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Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research

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PPARα Modulation-Based Therapy in Central Nervous System Diseases.

Deokho Lee^1,2, Yohei Tomita^1,2,3, William Allen³

¹Laboratory of Photobiology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Life (Basel, Switzerland)

|November 27, 2021

Summary

Peroxisome proliferator-activated receptors alpha (PPARα) show therapeutic potential for central nervous system (CNS) diseases. This review summarizes PPARα

Keywords:

central nervous system eye peroxisome proliferator-activated receptors

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Area of Science:

Neuroscience
Molecular Biology
Pharmacology

Background:

Global increase in neurodegenerative diseases affecting the central nervous system (CNS).
Inflammatory responses and metabolic derangements are key risk factors for CNS diseases.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors regulating cellular metabolism.

Purpose of the Study:

To comprehensively review the therapeutic roles of PPARα modulation in CNS diseases.
To highlight recent advances in PPARα's role in brain, spinal cord, and eye conditions.
To explore PPARα as a therapeutic target for preventing and treating CNS diseases.

Main Methods:

Literature review focusing on studies investigating PPARα modulation in CNS diseases.
Analysis of recent advances in understanding PPARα's mechanisms and therapeutic applications.
Synthesis of findings related to PPARα's impact on neuroinflammation and metabolic pathways.

Main Results:

PPARα modulation demonstrates significant therapeutic potential in preclinical and clinical studies for various CNS diseases.
PPARα influences key signaling pathways involved in neuroprotection, anti-inflammation, and metabolic homeostasis within the CNS.
Specific examples of PPARα's beneficial effects are detailed for conditions affecting the brain, spinal cord, and eye.

Conclusions:

PPARα represents a promising therapeutic target for managing and preventing neurodegenerative diseases.
Further research into PPARα modulation can lead to novel therapeutic strategies for CNS disorders.
This review provides a foundation for developing comprehensive approaches targeting PPARα.