Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

463
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
463
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

523
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
523
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

969
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
969
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

9
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
9
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

846
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
846
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

8
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
8

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversible formation of <i>S</i>-d-3-phosphoglyceroyl glutathione contributes to cellular protection from acylation by cyclic 3-phosphoglyceric anhydride.

RSC chemical biology·2026
Same author

Procyanidins: Structural Properties, Production Methods, and Modern Applications.

Molecules (Basel, Switzerland)·2026
Same author

Chemical composition and ecological adaptation of <i>Populus</i> (Salicaceae) species and hybrids depending on soil and environmental conditions.

RSC advances·2026
Same author

Green Synthesis and Characterization of Silver Nanoparticles Using <i>Artemisia terrae-albae</i> Extracts and Evaluation of Their Cytogenotoxic Effects.

International journal of molecular sciences·2025
Same author

Medicinal Plants for Skin Disorders: Phytochemistry and Pharmacological Insights.

Molecules (Basel, Switzerland)·2025
Same author

Pharmaco-Technological Characterization, Structural Analysis, and Toxicological Evaluation of the Novel Polyene Antibiotic Roseofungin for Drug Development.

Pharmaceutics·2025
Same journal

Correction: Iliuta et al. Impact of Pulmonary Hypertension on Mortality After Surgery for Aortic Stenosis. <i>Medicina</i> 2022, <i>58</i>, 1231.

Medicina (Kaunas, Lithuania)·2026
Same journal

Prognostic Value of BUN-Based Ratios for Mortality and Prolonged Hospitalization in Acute Upper Gastrointestinal Bleeding: Comparison with Established Risk Scores.

Medicina (Kaunas, Lithuania)·2026
Same journal

One-Year Comparative Outcomes of Conventional Versus Accelerated Corneal Cross-Linking in Progressive Keratoconus.

Medicina (Kaunas, Lithuania)·2026
Same journal

Beyond the Intestinal Mucosa in Long-Standing Inflammatory Bowel Disease: Consequences of Chronic Inflammation and Endoscopic Approaches to Diagnosis and Management.

Medicina (Kaunas, Lithuania)·2026
Same journal

Biological and Metabolic Correlates of Psychological Resilience in Maintenance Hemodialysis: An Exploratory Gender-Based Study.

Medicina (Kaunas, Lithuania)·2026
Same journal

Influence of Mitral Annular Calcification Assessed by Cardiac Computed Tomography on Procedural and Clinical Outcomes of Transcatheter Aortic Valve Implantation.

Medicina (Kaunas, Lithuania)·2026
See all related articles

Related Experiment Video

Updated: Oct 12, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K

Peptide-Based Drug Delivery Systems.

Dmitriy Berillo1, Adilkhan Yeskendir2, Zharylkasyn Zharkinbekov2

  • 1Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan.

Medicina (Kaunas, Lithuania)
|November 27, 2021
PubMed
Summary
This summary is machine-generated.

Peptide-based drug delivery systems offer superior biocompatibility and reduced toxicity compared to synthetic alternatives. This review highlights their potential for targeted delivery of toxic drugs, improving patient outcomes.

Keywords:
cell penetrating peptidesdrug carriersdrug delivery systempeptide-basedscaffoldsstimuli responsivetargeted delivery

More Related Videos

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.1K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.3K

Related Experiment Videos

Last Updated: Oct 12, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.1K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.3K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Synthetic drug delivery systems can cause side effects and struggle with blood-brain barrier penetration.
  • Peptide-based systems offer enhanced biocompatibility, controlled properties, and reduced toxicity.
  • There is a need to analyze non-toxic drug delivery systems and future trends.

Purpose of the Study:

  • To review recent advancements (past 5 years) in peptide-based drug delivery carriers.
  • To explore the use of peptide carriers for toxic drugs, including anticancer agents and those with limited bioavailability.
  • To establish prospective trends in developing advanced drug delivery systems.

Main Methods:

  • Literature review focusing on peptide-drug conjugates, nanoparticles, micelles, and self-assembly scaffolds.
  • Analysis of peptide-based platforms for delivering small molecules and therapeutic proteins.
  • Examination of cell-penetrating peptides and stimuli-responsive peptide systems.

Main Results:

  • Peptide-based platforms include peptide-drug conjugates, injectable particles, and depots.
  • These systems effectively deliver anticancer drugs and peptides, potentially accelerating recovery with fewer side effects.
  • Cell-penetrating and stimuli-responsive peptides offer targeted delivery mechanisms.

Conclusions:

  • Peptide-based drug delivery systems present a promising, non-toxic alternative to synthetic methods.
  • Future trends involve advanced peptide carriers, including self-assembling scaffolds and stimuli-responsive systems.
  • These platforms hold significant potential for improved therapeutic outcomes in cancer treatment and beyond.