Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.4K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

563
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
563
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.3K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.3K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

98
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
98
Desmosomes01:05

Desmosomes

5.9K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
5.9K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

163
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
163

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical profile of systemic sclerosis without a 'scleroderma pattern' at nailfold capillaroscopy: results from the multicenter SPRING registry of the Italian Society of Rheumatology.

Journal of translational autoimmunity·2026
Same author

Real-World Effectiveness of Baricitinib in Rheumatoid Arthritis: Significant Reduction of Disease Activity Independent of Age in a Multicentre Retrospective Cohort Study.

Mediterranean journal of rheumatology·2026
Same author

When Does Rectus Diastasis Worsen the Most? A Pregnancy-Order Analysis of Midline Fascial Failure.

Aesthetic plastic surgery·2026
Same author

Ixekizumab Treatment Persistence in Psoriatic Arthritis: Response to Joaquin et al.

Journal of psoriasis and psoriatic arthritis·2026
Same author

Real-world effectiveness and safety of apremilast in psoriatic arthritis: results from the multicenter Italian MAPSI II study.

Clinical rheumatology·2026
Same author

Six months predictors of DAPSA Remission With Guselkumab in Psoriatic Arthritis in a Multicenter Real-World Study.

Scientific reports·2026

Related Experiment Video

Updated: Oct 12, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.3K

Clinical and Histopathological Features of Scleroderma-like Disorders: An Update.

Rosario Foti1, Rocco De Pasquale2, Ylenia Dal Bosco1

  • 1Division of Reumathology, A.O.U. "Policlinico-San Marco", 95123 Catania, Italy.

Medicina (Kaunas, Lithuania)
|November 27, 2021
PubMed
Summary

Scleroderma-like disorders present diverse clinical and pathological features. Differentiating them from systemic sclerosis relies on the absence of antinuclear antibodies, Raynaud

Keywords:
cutaneous sclerosisscleredemascleroderma-likesclerodermiform mucinosis

More Related Videos

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

263
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

328

Related Experiment Videos

Last Updated: Oct 12, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.3K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

263
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

328

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Scleroderma-like disorders encompass various conditions affecting skin, subcutaneous tissue, and muscle.
  • Multiple pathogenetic mechanisms contribute to diverse clinical and pathological presentations.

Purpose of the Study:

  • To outline differential diagnostic criteria for scleroderma-like disorders.
  • To emphasize key distinguishing features from systemic sclerosis.

Main Methods:

  • Clinical evaluation of affected body sites and disease evolution.
  • Assessment of associated pathological conditions.
  • Histological examination of tissue samples.

Main Results:

  • Absence of antinuclear antibodies (ANA), Raynaud's phenomenon, and capillaroscopic anomalies are crucial for differential diagnosis.
  • Specific histological findings aid in correct diagnosis.

Conclusions:

  • Accurate diagnosis of scleroderma-like disorders requires exclusion of systemic sclerosis based on clinical, serological, and histological data.
  • Careful consideration of body site involvement, disease progression, and comorbidities is essential.