Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental...

Area of Science:

• Nanomedicine
• Pharmaceutical Sciences
• Biomaterials Engineering

Background:

• Calcium Phosphate nanoparticles (CaPs) show potential for lung-to-heart drug delivery to myocardial cells.
• Developing effective inhalation systems is crucial for targeted nanomedicine delivery.

Purpose of the Study:

• To develop a novel, highly respirable dry powder formulation embedding crystalline CaPs.
• To optimize the formulation using a Quality by Design approach for inhalation applications.

Main Methods:

• Spray drying technique was employed to create dry microparticles using mannitol as a matrix excipient.
• A Quality by Design approach investigated the impact of feed composition and spray rate on powder attributes.
• In vitro aerodynamic performance, inner structure, and morphology of microparticles were evaluated.

Main Results:

• The 1:4 ratio of CaPs to mannitol resulted in hollow microparticles with superior aerodynamic performance.
• Spray drying successfully produced respirable dry powders.
• Released CaPs maintained their original size after microparticle dissolution.

Conclusions:

• Hollow microparticles formulated with a 1:4 CaPs/mannitol ratio are promising for inhalation drug delivery.
• The developed system facilitates targeted lung-to-heart delivery of CaPs to myocardial cells.
• This approach offers a viable strategy for novel nanomedicine delivery systems.