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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Targeting Engineered Nanoparticles for Breast Cancer Therapy.

Kumar Ganesan1, Yan Wang1, Fei Gao2

  • 1Li Ka Shing Faculty of Medicine, School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.

Pharmaceutics
|November 27, 2021
PubMed
Summary

Engineered nanoparticles (NPs) offer a promising approach to selectively target breast cancer (BC) cells, improving treatment efficacy and reducing side effects compared to traditional therapies.

Keywords:
breast cancerengineeringligandsnanoparticlestherapeutic effects

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Breast cancer (BC) is a leading global cancer in women, with current treatments like surgery, radiotherapy, and chemotherapy often causing significant side effects and damaging healthy tissues.
  • The limitations of conventional BC therapies necessitate the development of more targeted and effective treatment strategies.
  • Nanoparticles (NPs) have emerged as a potential solution for targeted drug delivery in cancer treatment.

Purpose of the Study:

  • To review the role of engineered nanoparticles (NPs) and their payloads in the targeted treatment of breast cancer (BC).
  • To explore the design principles and therapeutic potential of NPs for BC management.
  • To highlight NPs as a next-generation platform for BC prevention and therapy.

Main Methods:

  • Comprehensive literature review of studies on engineered NPs for BC treatment.
  • Searches conducted in PubMed, Science Direct, and Google Scholar databases.
  • Analysis of NP synthesis, payload incorporation, targeting strategies, and therapeutic impact on BC.

Main Results:

  • Engineered NPs can enhance the solubility, circulation time, and biodistribution of therapeutic agents.
  • NPs can be functionalized with ligands (peptides, antibodies, nucleic acids) for precise targeting of BC cells.
  • This targeted approach minimizes damage to healthy tissues and reduces treatment-related side effects.

Conclusions:

  • Engineered NPs represent a significant advancement in breast cancer therapy, offering targeted delivery and reduced toxicity.
  • The strategic design of NPs, including size, shape, and surface modification, is crucial for optimizing therapeutic outcomes.
  • Further validation of engineered NPs is essential for their implementation as a next-generation platform for BC prevention and treatment.