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Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release
Meie Chao1, Heidi Öblom1,2, Claus Cornett1
1Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Pharmaceutics
|November 27, 2021
Summary
Data-enriched edible pharmaceuticals (DEEP) offer personalized medicine with flexible dosing and embedded data via QR codes. This study fabricated DEEP using cannabinoids, demonstrating customizable designs and dose flexibility, with potential for patient-preferred medicine.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Personalized Medicine
Background:
- Traditional pharmaceuticals lack personalization in dosing and patient-specific design.
- Data-enriched edible pharmaceuticals (DEEP) integrate digital information into dosage units.
- Quick Response (QR) codes enable data embedding at the single dosage unit level.
Purpose of the Study:
- To fabricate DEEP with patient-tailored doses and customizable designs.
- To modify drug release profiles and enhance patient preferences.
- To assess the physical stability and QR code readability of DEEP during storage.
Main Methods:
- Utilized desktop inkjet printing to fabricate DEEP with cannabinoids (CBD, THC).
- Explored various substrates, colorants, and QR code designs (patterns, images, size) for customization.
- Applied hydroxypropyl cellulose (HPC) polymer coating to modify drug release and assess stability.
Main Results:
- Achieved flexible dosing and customizable DEEP designs by manipulating QR code parameters.
- HPC coating modified drug release but did not fully preserve QR code readability under extreme conditions (40 °C, 75% RH).
- DEEP maintained appearance and readability under cold, dry storage conditions.
Conclusions:
- The DEEP concept facilitates personalized medicine by enabling flexible dosing and patient-specific designs.
- DEEP technology offers a platform for integrating data and customization into pharmaceutical dosage forms.
- Further research is needed to optimize coating strategies for enhanced stability under adverse storage conditions.
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