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Microbial Fibrinolytic Enzymes as Anti-Thrombotics: Production, Characterisation and Prodigious Biopharmaceutical

Chhavi Sharma1, Alexander Osmolovskiy2, Rajni Singh1

  • 1Amity Institute of Microbial Technology, Amity University Uttar Pradesh, Noida 201313, India.

Pharmaceutics
|November 27, 2021
PubMed

Insights

Microbial fibrinolytic enzymes offer a cost-effective and safe alternative to traditional treatments for cardiovascular disorders. These enzymes effectively dissolve blood clots and have diverse applications beyond thrombolysis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disorders, including myocardial infarction and stroke, are often caused by excessive fibrin accumulation leading to thrombosis.
  • Current anti-thrombotic strategies have limitations, including undesirable side effects and high costs.

Purpose of the Study:

  • To review the production, properties, and applications of microbial fibrinolytic enzymes.
  • To highlight their potential as a safer and more cost-effective therapeutic option for thrombosis.

Main Methods:

  • Exploration of microbial sources for fibrinolytic enzyme discovery.
  • Analysis of enzyme purification, biochemical characterization, and structural-functional attributes.
  • Investigation of strain improvement and genetic engineering for enhanced enzyme production.

Main Results:

  • Microbial fibrinolytic enzymes demonstrate high efficacy in hydrolyzing thrombi with minimal side effects.
  • These enzymes can be produced affordably on a large scale.
  • Beyond thrombolysis, they exhibit diverse applications including protein hydrolysis, blood pressure regulation, and antimicrobial activity.

Conclusions:

  • Microbial fibrinolytic enzymes represent a promising avenue for managing cardiovascular diseases.
  • Their versatile applications extend to various industrial and therapeutic fields.
  • Further research into novel enzymes and genetic modification can enhance their therapeutic potential.

Keywords:
biopharmaceutical applicationscharacterisationenzyme productionenzyme purificationmicrobial fibrinolytic enzymesstructural-functional attributesthrombolytic potential

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