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Pharmacogenomic Testing and Patient Perception Inform Pain Pharmacotherapy
Feng-Hua Loh1, Brigitte Azzi1, Alexander Weingarten2
1Touro College of Pharmacy, New York, NY 10027, USA.
Journal of Personalized Medicine
|November 27, 2021
Summary
Pharmacogenomic testing guides pain medication choices, improving patient outcomes. Over 50% of patients had altered prescriptions, leading to reduced intense pain and better treatment efficacy.
Area of Science:
- Pharmacogenomics
- Pain Management
- Clinical Pharmacology
Background:
- Chronic pain affects many individuals, with opioids historically used for management.
- Opioid efficacy and toxicity vary due to individual genetic differences.
- Pharmacogenomic testing aims to optimize medication selection and treatment outcomes.
Purpose of the Study:
- To assess the impact of CYP2D6 pharmacogenomic testing on prescribing habits for chronic pain.
- To evaluate the effect of pharmacogenomic testing on patient pain control.
Main Methods:
- Retrospective review of 107 patient charts from a pain management center.
- All patients underwent pharmacogenomic testing.
- Outcomes included confirmation of optimal medication or need for change based on test results.
Main Results:
- Over 50% of patients had their pain medications altered post-pharmacogenomic testing.
- Intense pain decreased from 10.5% pre-testing to 5.6% post-testing.
- Changes in medication or dose were associated with decreased pain scores; Hispanic ethnicity and illegal drug abuse also correlated with pain reduction.
Conclusions:
- Pharmacogenomic testing significantly benefits patients with intense pain.
- Testing aids in optimizing pain medication selection and improving patient pain control.
- Personalized medicine approaches, guided by pharmacogenomics, are crucial for effective chronic pain management.
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