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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study.

Sung-Hwa Ko^1,2, Taehyung Kim², Ji Hong Min^1,2

¹Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.

Journal of Personalized Medicine

|November 27, 2021

Summary

This summary is machine-generated.

Injury to the corticoreticular pathway (CRP) after stroke is linked to post-stroke spasticity (PSS). Diffusion tensor imaging (DTI) revealed altered CRP integrity in patients with spasticity, suggesting a pathophysiological connection.

Keywords:

corticoreticular pathway diffusion tensor imaging reticulospinal tract spasticity stroke

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Post-stroke spasticity (PSS) is a common and debilitating condition.
A key pathophysiology involves reticulospinal tract (RST) imbalance due to corticoreticular pathway (CRP) injury following stroke.

Purpose of the Study:

To investigate the relationship between CRP injuries and PSS using MR diffusion tensor imaging (DTI).
To explore the role of CRP integrity in the development of PSS.

Main Methods:

Retrospective analysis of 70 ischemic stroke patients.
Classification into spasticity and control groups.
Measurement of ipsilesional fractional anisotropy (iFA) and contralesional fractional anisotropy (cFA) values in the reticular formation (RF) of the CRP using DTI.

Main Results:

Patients with PSS exhibited lower contralesional fractional anisotropy (cFA) values in the CRP compared to controls (p=0.04).
Sub-region analysis showed reduced ipsilesional fractional anisotropy (iFA) in the pontine RF for both groups (p<0.05).
The spasticity group displayed lower cFA values in the medullary RF compared to ipsilesional values and control cFA values (p<0.05).

Conclusions:

CRP injury and subsequent RST imbalance are associated with PSS.
DTI analysis of the CRP provides valuable imaging evidence for understanding PSS pathophysiology.