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The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence

Marienela Y Heredia1, Jason M Rauceo1

  • 1Department of Sciences, John Jay College of the City University of New York, New York, NY 10019, USA.

Microorganisms
|November 27, 2021
PubMed

Insights

Integral membrane proteins called SPFH (stomatin, prohibitin, flotillin, HflK/HflC) are vital in fungi. Their roles in filamentation and stress signaling suggest potential as antifungal drug targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Mycology

Background:

  • SPFH proteins are ancient integral membrane proteins found across all domains of life.
  • In mammals, SPFH proteins are linked to mitochondrial function, ion transport, signaling, and mechanosensation.
  • SPFH proteins are essential for parasite virulence.

Purpose of the Study:

  • To review the functions of SPFH proteins in various fungal species.
  • To highlight the potential of SPFH proteins as antifungal drug targets, particularly in *Candida albicans*.

Main Methods:

  • Literature review of existing research on SPFH proteins in fungi.
  • Analysis of conserved and unique roles of SPFH proteins in fungal physiology.
  • Exploration of therapeutic implications based on SPFH protein functions.

Main Results:

  • SPFH proteins are conserved in fungi, primarily associated with mitochondrial functions.
  • Fungal SPFH proteins have additional roles in filamentation and stress signaling.
  • SPFH protein inhibitors are effective in cancer and inflammation, indicating potential for antifungal drug development.

Conclusions:

  • SPFH proteins play crucial roles in fungal biology beyond mitochondrial functions.
  • Targeting SPFH proteins represents a promising strategy for developing novel antifungal therapies.
  • Further research into SPFH proteins in *Candida albicans* is warranted for drug development.
Keywords:
SPFHfungimitochondriaprohibitinstomatin

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