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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

957
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
957
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

746
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
746
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

885
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
885

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Related Experiment Video

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Aniridic glaucoma: An update.

F J Muñoz-Negrete1, M A Teus2, J García-Feijoó3

  • 1Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain; Universidad de Alcalá, Alcalá de Henares, Spain; OFTARED.

Archivos De La Sociedad Espanola De Oftalmologia
|November 27, 2021
PubMed
Summary
This summary is machine-generated.

Aniridic glaucoma (AG) affects over 50% of individuals with aniridia, a congenital eye disorder. Management involves medical therapy and surgical interventions, with choices varying based on glaucoma type.

Keywords:
AniridiaAniridic glaucomaCongenital glaucomaGlaucomaGlaucoma anirídicoGlaucoma congénitoGlaucoma infantilInfantile glaucoma

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Area of Science:

  • Ophthalmology
  • Genetics
  • Glaucoma Research

Background:

  • Aniridia is a congenital bilateral ocular disorder with dominant autosomal inheritance.
  • Over 50% of aniridia patients develop aniridic glaucoma (AG).
  • AG presents diagnostic challenges due to keratopathy, nystagmus, and foveal hypoplasia, with corneal thickness impacting intraocular pressure measurement.

Purpose of the Study:

  • To review the characteristics, diagnosis, and management of aniridic glaucoma (AG).
  • To discuss current treatment strategies for both open-angle and closed-angle mechanisms in AG.

Main Methods:

  • Literature review of aniridic glaucoma (AG) cases and treatment outcomes.
  • Analysis of diagnostic difficulties and therapeutic options for AG.

Main Results:

  • Aniridic glaucoma can manifest with open-angle or closed-angle mechanisms.
  • Medical treatment for AG is similar to general glaucoma, favoring preservative-free and combination therapies.
  • Surgical approaches differ: angle surgery for open-angle AG, and glaucoma drainage devices for closed-angle AG.

Conclusions:

  • Aniridic glaucoma requires tailored management strategies.
  • Surgical intervention is frequently necessary, with specific procedures recommended based on the underlying mechanism of AG.