Smartphone-Based Electrochemical System for Biosensors and Biodetection.
Daizong Ji1, Sze Shin Low1, Diming Zhang1
1Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, People's Republic of China.
Methods in Molecular Biology (Clifton, N.J.)
|November 27, 2021
Summary
Smartphones enable portable electrochemical biosensors by integrating with modified electrodes for detecting various analytes. This technology offers a promising, miniaturized alternative for point-of-care testing (POCT).
Area of Science:
- Electrochemistry
- Biosensors
- Mobile Health
Background:
- Smartphones offer advantages like high resolution imaging and computing power, making them suitable for detection systems.
- Their popularity and open-source nature facilitate integration into various analytical platforms.
- Electrochemical and optical detection methods are increasingly leveraging smartphone capabilities.
Purpose of the Study:
- To explore the application of smartphones in electrochemical detection and optical detection systems.
- To demonstrate the development of smartphone-based biosensors using modified electrodes for biodetection.
- To highlight the potential of these systems for point-of-care testing (POCT).
Main Methods:
- Smartphone-based electrochemical systems were coupled with screen-printed and interdigital electrodes.
- Electrodes were modified with diverse materials including nanomaterials (graphene, nanoparticles, carbon nanotubes) and biomaterials (proteins, antibodies).
- Impedance and amperometric techniques were employed for analyte detection.
Main Results:
- Modified electrodes enabled the detection of various analytes such as acetone, proteins (albumin), explosives (trinitrotoluene), and neurotransmitters (glucose, dopamine).
- Smartphone-based impedance systems detected acetone, bovine serum albumin, human serum albumin, and trinitrotoluene.
- Smartphone-based amperometric systems monitored glucose, ascorbic acid, dopamine, uric acid, and levodopa.
Conclusions:
- Smartphone-based electrochemical systems offer a miniaturized and portable solution for biodetection.
- These systems, utilizing modified electrodes, show significant promise for point-of-care testing (POCT) applications.
- The integration of smartphones enhances the accessibility and utility of electrochemical biosensors.
