Related Experiment Video
Updated: Oct 11, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Risk Factors for the Development of Pneumonia and Severe Pneumonia in Children
Jagdish Prasad Goyal1, Prawin Kumar2, Aparna Mukherjee3
1Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan. Correspondence to: Dr. Jagdish Prasad Goyal, Professor, Department of Pediatrics, AIIMS, Jodhpur 340 003, Rajasthan. jpgoyal@rediffmail.com.
Insights
Young children and those with undernutrition are at higher risk for pneumonia. This study identified key risk factors for childhood pneumonia and severe pneumonia in India.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Pneumonia remains a leading cause of child mortality globally.
- Identifying risk factors is crucial for effective prevention and intervention strategies.
Purpose of the Study:
- To determine the risk factors associated with pneumonia and severe pneumonia in children.
- To inform public health initiatives aimed at reducing childhood pneumonia.
Main Methods:
- Prospective cohort study conducted across five tertiary-care teaching hospitals in India.
- Enrolled 7026 children aged 2 to 59 months with acute respiratory infection (ARI).
- Assessed risk factors for World Health Organization (WHO) defined pneumonia and severe pneumonia.
Main Results:
- 13.4% of enrolled children were diagnosed with pneumonia, and 36.9% of those had severe pneumonia.
- Univariate analysis indicated younger age, male gender, and low weight-for-height as significant risk factors.
- Multivariate analysis revealed a protective effect of increased age and weight-for-height z-score.
Conclusions:
- Young age and undernutrition (low weight-for-height/length) are significant independent risk factors for childhood pneumonia.
- Findings highlight the importance of nutritional status and age in pneumonia risk assessment.
- The study provides valuable data for targeted interventions in high-risk pediatric populations.
Objective:
To identify the risk factors for pneumonia and severe pneumonia in children.
Design:
Prospective cohort study.
Setting:
Five tertiary-care teaching hospitals in India.
Participants:
Children 2 to 59 months of age suffering from acute respiratory infection (ARI).
Main Outcome Measures:
Risk factors for the development of WHO defined pneumonia and severe pneumonia.
Result:
A total of 18159 children screened, and 7026 (39%) children with ARI were enrolled. According to the WHO criteria, 938 (13.4%) and 6088 (86.6%) of the enrolled children had pneumonia and no pneumonia, respectively. Out of 938 children with pneumonia, 347 (36.9%) had severe pneumonia. On univariate analysis, younger age, male gender and low weight for height, were significant risk factors for pneumonia. On multivariate analysis, one-unit increase in age in months (OR = 0.97; 95% CI: 0.97-0.98) and weight for height z-score (OR = 0.76; 95% CI: 0.72-0.79) had a protective effect.
Conclusions:
Young age and undernutrition (low weight for height/length) in children are significant independent risk factors for pneumonia.
More Related Videos
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
07:43A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice
Published on: September 28, 2016
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment
Pneumonia II: Pathophysiology
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pulmonary Cycle: Exhalation