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Updated: Oct 11, 2025

Sperm Collection of Differential Quality Using Density Gradient Centrifugation
Published on: November 29, 2018
Sperm Associated Antigens: Vigorous Influencers in Life
Samaneh Faraji1,2, Mohsen Sharafi3, Abdol Hossein Shahverdi2,4
1Department of Molecular and Cellular Biology, Faculty of Basic Science and Advanced Technologies in Biology, University of Science and Culture, ACECR, Tehran, Iran.
Abstract:
Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.
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