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Updated: Aug 2, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Structural anomalies in a published NMR-derived structure of IRAK-M

Hessel Poelman1, Hans Ippel2, Berke Gürkan3

  • 1Amsterdam UMC, University of Amsterdam, Medical Biochemistry, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.

Journal of Molecular Graphics & Modelling
|November 27, 2021
PubMed
Summary

The Toll-Like Receptor and Interleukin-1 Receptor (IL1-R) pathway relies on MyD88 and IL-1R Associated Kinases (IRAKs). A new study identified structural anomalies in the IRAK-M death domain NMR structure (5UKE), proposing a refined model for better accuracy.

Keywords:
5UKEDALIHomology modelingIRAK-MMyddosomeNMRStructure validationTALOS-NWHAT_CHECKYasara

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