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Updated: Oct 11, 2025
Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
Graphene oxide enriched with oxygen-containing groups: on the way to an increase of antioxidant activity and
Abdelsattar O E Abdelhalim1, Anatolii A Meshcheriakov2, Dmitrii N Maistrenko3
1Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, Russia; Environmental Research Department, National Center for Social and Criminological Research (NCSCR), 4 Agouza, Giza, 11561, Egypt.
Abstract:
The article is dedicated to the comprehensive biocompatibility investigation of synthesised graphene oxide (GO) enriched with oxygen-containing functional groups (⁓85%). GO was synthesised through a modified Hummers and Offeman's method and characterised using 13C NMR, Raman, and IR spectroscopy, XRD, HRTEM, along with size dimensions and ζ-potentials in aqueous dispersions. Biocompatibility study included tests on haemocompatibility (haemolysis, platelet aggregation, binding to human serum albumin and its esterase activity), antioxidant activity (2,2-diphenyl-1-picrylhydrazyl reaction, NO-radical uptake, Radachlorin photobleaching, photo-induced haemolysis), genotoxicity using DNA comet assay, as well as metabolic activity and proliferation of HEK293 cells.
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