Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

327
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
327
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.4K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

2.7K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
2.7K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

657
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
657
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

45
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
45
Hand hygiene01:23

Hand hygiene

4.5K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Pediatric psoriasis: from immunogenetics to targeted therapies.

Anais brasileiros de dermatologia·2026
Same author

The intergluteal cleft lesion in hidradenitis suppurativa: clinical characteristics and potential clinical implications.

Anais brasileiros de dermatologia·2026
Same author

The worldwide burden of skin diseases: Lessons from the Global Burden of Disease data.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Erythrodermic crusted scabies in an immunocompetent three-month-old infant with marked systemic inflammation.

Anais brasileiros de dermatologia·2026
Same author

Sweet syndrome with reactive lymphadenopathy mimicking metastatic disease in an <i>SDHB</i>-mutated abdominal paraganglioma.

JCEM case reports·2026
Same author

Effect of methotrexate on endothelial function in psoriasis patients.

The Journal of dermatological treatment·2026

Related Experiment Video

Updated: Oct 11, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.1K

Generalized pustular psoriasis (von Zumbusch).

Ricardo Romiti1, André Luís da Silva Hirayama1, Marcelo Arnone1

  • 1Department of Dermatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Anais Brasileiros De Dermatologia
|November 28, 2021
PubMed
Summary
This summary is machine-generated.

Generalized pustular psoriasis (von Zumbusch) is a rare, acute skin condition with sterile pustules. Prompt diagnosis and intervention are crucial due to its severe systemic potential and limited treatment options.

Keywords:
AcrodermatitisPsoriasisPsoriasis/epidemiologyPsoriasis/geneticsPsoriasis/physiopathologyPsoriasis/therapy

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

532
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K

Related Experiment Videos

Last Updated: Oct 11, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.1K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

532
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K

Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Background:

  • Generalized pustular psoriasis (von Zumbusch) is a rare, acute skin condition.
  • Characterized by sterile pustules on erythematous, edematous skin, often with psoriasis vulgaris.
  • Can present with severe systemic manifestations requiring urgent medical attention.

Purpose of the Study:

  • To summarize the key features of generalized pustular psoriasis.
  • To highlight the diagnostic and therapeutic challenges.
  • To mention recent advances in understanding its genetic basis.

Main Methods:

  • Literature review of generalized pustular psoriasis.
  • Analysis of clinical presentation and diagnostic criteria.
  • Review of current and emerging therapeutic strategies.

Main Results:

  • Generalized pustular psoriasis is a severe condition with variable flare durations.
  • Genetic abnormalities are increasingly identified in familial and early-onset cases.
  • Current treatments are limited, with new therapies under investigation.

Conclusions:

  • Prompt diagnosis and intervention are critical for managing generalized pustular psoriasis.
  • Understanding genetic factors is advancing disease characterization.
  • New therapeutic agents are being developed to manage flare-ups and recurrences.