Related Experiment Video
Updated: Oct 11, 2025
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.8K
Sustained symptomatic remission in schizophrenia: Course and predictors from a two-year prospective study
Bernardo Carpiniello1, Federica Pinna1, Mirko Manchia2
1Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy.
Schizophrenia Research
|November 28, 2021
Summary
This study found that more stringent remission criteria in schizophrenia are more stable over time. Negative symptoms predict stable remission, while cognitive symptoms and illness duration predict remission duration.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Remission rates in psychosis vary significantly across studies and over time.
- Methodological differences contribute to variability in reported remission rates.
- Optimal assessment procedures and reliable predictors of remission are needed.
Purpose of the Study:
- To longitudinally compare remission status using different criteria in schizophrenia and schizoaffective disorder.
- To identify predictors of remission duration and stability.
Main Methods:
- 112 patients with schizophrenia or schizoaffective disorder were followed for 24 months.
- Remission was assessed using Remission in Schizophrenia Working Group (RSWG), PANSS positive and negative scales (PANSS-PN), and PANSS total score (PANSS-T).
- Kaplan-Meier survival analysis and regression models were used to analyze data.
Main Results:
- At baseline, 50% of patients met RSWG criteria, compared to 23.2% for other criteria.
- PANSS-T remission rates demonstrated the highest stability.
- Negative symptoms predicted stable remission for RSWG criteria; cognitive symptoms and illness duration predicted PANSS-T remission duration.
Conclusions:
- More stringent remission criteria exhibit greater stability over time.
- Basal clinical predictors play a significant role in remission.
- Using stringent criteria may optimize clinical evaluations and improve prediction of remission outcomes.
Related Concept Videos
01:26Psychosis: Goals of Pharmacotherapy
255
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
255
01:29Psychological and Sociocultural Causes of Schizophrenia
226
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
226
01:28Psychosis and Antipsychotic Drugs: Overview
525
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
525
01:17Schizophrenia
294
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
294
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.1K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.1K
01:28Drug Therapy
116
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
116