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Updated: Oct 11, 2025

Autofluorescence Imaging to Evaluate Cellular Metabolism
Published on: November 15, 2021
[Advances in research on the relationship between changes in cellular metabolism and lung diseases]
Menglu Xu1, Yiding Zuo, Li Zhou
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Corresponding author: Jiang Chunling,
Abstract:
As the place for gas exchange, the lungs are metabolically active, and their energy consumption are essential for regulating common cell functions and maintaining the unique function of lung tissues to synthesize pulmonary surfactants. The metabolic pathways of pulmonary cells mainly include glycolysis, pentose phosphate pathway, and tricarboxylic acid cycle. Recent studies have found that changes in pulmonary cells metabolism are closely related to a variety of lung diseases. Herein, we review the main pathways of pulmonary cells metabolism and the relationship between changes in cell metabolism and the four lung diseases of chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension (PH), to find new ways to treat lung diseases.
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