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An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects
Published on: January 9, 2020
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Measurement methods of single cell drug response
Yuliang Zhao1, Jiazhi Lou1, Hongyu Zhang1
1School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, 066004, China.
Talanta
|November 29, 2021
Summary
Single cell drug response (SCDR) measurement technologies offer a faster, more accurate way to evaluate drug efficacy, reducing costs and development time. This review compares sixteen SCDR technologies to guide future advancements in drug discovery and disease treatment.
Area of Science:
- Biotechnology
- Pharmacology
- Cell Biology
Background:
- Drug development faces challenges with high costs and low efficiency.
- Single cell drug response (SCDR) measurement provides a more direct and accurate assessment of drug efficacy.
- SCDR technologies are crucial for shortening drug development timelines and reducing research expenses.
Purpose of the Study:
- To review and compare sixteen single cell drug response measurement technologies.
- To evaluate SCDR technologies based on signal-to-noise ratio, throughput, content, invasiveness, and device complexity.
- To classify SCDR technologies into electrical, optical, electrochemical, and mass spectrometry categories.
Main Methods:
- Literature review of SCDR measurement technologies over the past forty years.
- Analysis of sixteen representative SCDR technologies, including patch-clamp, live-cell interferometry, capillary electrophoresis, and mass spectrometry.
- Classification of technologies based on their underlying reaction principles.
Main Results:
- Sixteen SCDR measurement technologies were identified and analyzed.
- Technologies were categorized into four main groups: electrical, optical, electrochemical, and mass spectrometry.
- A detailed comparison of these technologies based on key performance criteria was conducted.
Conclusions:
- Understanding and comparing SCDR technologies is vital for improving drug efficacy assessment.
- Future work should focus on enhancing or integrating existing SCDR technologies for better drug development and screening.
- SCDR measurement holds potential for advancements in disease diagnosis and treatment strategies.
