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Updated: Oct 11, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
Published on: December 5, 2020
Multimodal immunostimulation to control BRCA1-defective ovarian carcinoma
Vanessa Klapp1, Lorenzo Galluzzi2
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Abstract:
Depending on intensity and duration, STING1 (stimulator of interferon response cGAMP interactor 1) signaling can restrain or promote tumor progression via both cancer cell-intrinsic and -extrinsic pathways. Bruand et al. recently identified a novel STING1-driven immunosuppressive pathway that can be targeted toward superior disease control in preclinical models of homologous recombination deficient (HRD) ovarian carcinoma.
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