Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

353
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
353
Seizures: Classification01:13

Seizures: Classification

666
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
666
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

340
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
340

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Characterizing Onset Limit and Surgical Outcome Factors in Type II Focal Cortical Dysplasia-Related Epilepsy.

Neurology. Clinical practice·2026
Same journal

Efficacy and Safety of Perampanel in Patients With Brain Tumor-Related Epilepsy: A Systematic Review and Meta-Analysis.

Neurology. Clinical practice·2026
Same journal

Patient-Reported Symptom Burden in Individuals With Parkinson Disease.

Neurology. Clinical practice·2026
Same journal

Global Access to Diagnostic Paraclinical Testing Incorporated in the 2024 Revised McDonald Criteria: Disparities and Opportunity.

Neurology. Clinical practice·2026
Same journal

Clinical Differentiation of Self-Limited Epilepsy With Autonomic Seizures (Panayiotopoulos Syndrome) and Childhood Migraine.

Neurology. Clinical practice·2026
Same journal

The National Association of Epilepsy Centers Accreditation Criteria Should Include Care for People With Functional/Dissociative Seizures.

Neurology. Clinical practice·2026
See all related articles

Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
06:28

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

2.7K

Seizure Detection Devices: Five New Things.

Alexandra Carrick Atwood1, Cornelia Natasha Drees1

  • 1Department of Neurology, University of Colorado, Aurora.

Neurology. Clinical Practice
|November 29, 2021
PubMed
Summary
This summary is machine-generated.

Seizure detection devices (SDDs) show high sensitivity for convulsive seizures but struggle with specificity and nonconvulsive seizure detection. Future improvements are needed for comprehensive seizure monitoring and to help prevent sudden unexpected death in epilepsy.

More Related Videos

Surgical Implant Procedure and Wiring Configuration for Continuous Long-Term EEG/ECG Monitoring in Rabbits
08:36

Surgical Implant Procedure and Wiring Configuration for Continuous Long-Term EEG/ECG Monitoring in Rabbits

Published on: January 24, 2025

652
Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
10:25

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

6.2K

Related Experiment Videos

Last Updated: Oct 11, 2025

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
06:28

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

2.7K
Surgical Implant Procedure and Wiring Configuration for Continuous Long-Term EEG/ECG Monitoring in Rabbits
08:36

Surgical Implant Procedure and Wiring Configuration for Continuous Long-Term EEG/ECG Monitoring in Rabbits

Published on: January 24, 2025

652
Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
10:25

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

6.2K

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Epilepsy affects millions globally, necessitating reliable seizure monitoring.
  • Sudden unexpected death in epilepsy (SUDEP) remains a critical concern.
  • Current seizure detection methods have limitations in accuracy and scope.

Purpose of the Study:

  • To review existing seizure detection devices (SDDs) and their underlying mechanisms.
  • To evaluate the efficacy of current SDDs in clinical practice.
  • To identify areas for improvement in future seizure detection technologies.

Main Methods:

  • Systematic review of scientific literature on seizure detection devices.
  • Categorization of devices based on sensing modalities (EEG, HR, EDA, motion, EMG).
  • Analysis of device performance metrics, including sensitivity and specificity.

Main Results:

  • Five primary categories of SDDs exist: EEG, heart rate (HR), electrodermal activity (EDA), motion detection, and EMG.
  • SDDs demonstrate high sensitivity for convulsive seizures but low specificity due to artifact detection.
  • Current devices perform poorly in detecting nonconvulsive seizures.

Conclusions:

  • SDDs are most effective for detecting convulsive seizures, potentially aiding in SUDEP prevention.
  • A significant challenge remains the high false positive rate associated with current SDDs.
  • Existing devices are less adept at identifying subtle, nonconvulsive seizure events.