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SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study

Dabin Kuang1, Lichen Dong1, Lingyun Liu2

  • 1The Affiliated Changsha Hospital of Hunan Normal University, Changsha, Hunan 410006, China.

Biomed Research International
|November 29, 2021
PubMed

Insights

The Suppressor of Cytokine Signaling 3 (SOCS3) gene variant rs8064821 is linked to a higher risk of hypertension in the Chinese population. This genetic variation may influence hypertension risk by altering SOCS3 gene expression.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Endothelial inflammation and vascular damage are key risk factors for hypertension.
  • Suppressor of Cytokine Signaling 3 (SOCS3) plays a crucial role in regulating inflammatory pathways.
  • Previous research highlights SOCS3's anti-inflammatory effects in conditions like hypertension and obesity.

Purpose of the Study:

  • To investigate the association between a specific SOCS3 tagSNP (rs8064821) and hypertension risk in the Chinese population.
  • To explore the potential role of SOCS3 gene expression in hypertension development.

Main Methods:

  • A case-control study involving 532 hypertension patients and 569 healthy controls from central China.
  • Genotyping of the SOCS3 rs8064821 C>A polymorphism using the TaqMan assay.
  • Analysis of SOCS3 mRNA levels in peripheral blood mononuclear cells (PBMCs) from healthy donors.

Main Results:

  • The SOCS3 rs8064821 CA genotype was significantly associated with an increased risk of hypertension (OR = 1.821, P = 0.001).
  • The rs8064821 A allele was correlated with higher SOCS3 mRNA expression in PBMCs of healthy individuals.
  • These findings suggest a link between the SOCS3 C>A polymorphism and altered SOCS3 expression.

Conclusions:

  • The SOCS3 rs8064821 C>A polymorphism may contribute to hypertension susceptibility in the Chinese population.
  • The mechanism may involve the regulation of SOCS3 gene expression by this specific polymorphism.
  • This study provides genetic insights into the inflammatory pathways involved in hypertension.

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