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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

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[Subacute Thyroiditis Following HPV Vaccination: A Case Report].

Qian Xie¹, Xing-Yu Mu¹, Shuang-Qing Li¹

¹Department of General Practice, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition

|November 29, 2021

Summary

Subacute thyroiditis (SAT) is a painful thyroid condition. This case report details a rare instance of SAT developing after the 9-valent human papillomavirus vaccine, which resolved with treatment.

Keywords:

Adverse reaction Nine-valent human papillomavirus vaccine Pathogenesis Subacute thyroiditis

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Area of Science:

Endocrinology
Immunology
Vaccinology

Background:

Subacute thyroiditis (SAT) is a common, self-limiting thyroid disorder characterized by neck pain, often linked to viral infections.
While typically associated with viral infections, SAT following vaccination is exceptionally rare.

Observation:

A patient developed fever, neck pain, and fatigue approximately 8 hours after receiving the first dose of the 9-valent human papillomavirus vaccine (Gardasil 9).
Physical examination revealed a tender, enlarged thyroid gland. Laboratory tests indicated elevated inflammatory markers and thyroid antibodies.
Thyroid ultrasonography showed diffuse bilateral thyroid enlargement with an uneven echo pattern, leading to a diagnosis of SAT.

Findings:

The patient's symptoms, including fever and neck pain, significantly improved within 5 days of ibuprofen treatment.
Following the complete vaccination series, thyroid function normalized, and SAT did not recur during follow-up.

Implications:

This case highlights the potential, albeit rare, association between the 9-valent human papillomavirus vaccine and subacute thyroiditis.
It underscores the importance of considering vaccination as a potential trigger for SAT in clinical practice.
The successful management and lack of recurrence suggest that SAT post-vaccination may be transient and manageable.