[Vaginal microbiome: community characteristics and disease intervention]

Area of Science:

• Microbiology
• Genetics
• Medicine

Background:

• High-throughput sequencing has advanced human microbiome research.
• The human microbiome's role in disease development and precision medicine is critical.
• Vaginal microbiome research is gaining interest due to its link with genital tract diseases.

Purpose of the Study:

• To summarize the interactions between the vaginal microbiome and diseases.
• To review treatments for vaginal microbiome dysbiosis.
• To propose novel approaches for vaginal microbiome research and therapeutic interventions.

Main Methods:

• Literature review of studies on vaginal microbiome and disease.
• Analysis of current understanding of vaginal dysbiosis.
• Exploration of emerging technologies and strategies.

Main Results:

• Vaginal microbiome dysbiosis is closely associated with genital tract diseases.
• Existing treatments for dysbiosis are being evaluated.
• Novel approaches like culturomics, engineered probiotics, and synthetic microbiomes show promise.

Conclusions:

• Understanding the vaginal microbiome is crucial for diagnosing and treating related diseases.
• Targeting vaginal microbiome dysbiosis offers potential for precision medicine.
• Future research should focus on innovative culturomics, probiotics, and synthetic microbiome strategies.