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Updated: Oct 11, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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Isfahan Thyroid Cohort Study (ITCS).

Samaneh Shahrokh Esfahani1, Aliye Tabatabaee1, Ashraf Aminorroaya1

  • 1Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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|November 29, 2021
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Summary

The Isfahan Thyroid Cohort Study reveals significant prevalence of hypothyroidism and hyperthyroidism in Iran. Ongoing research aims to link thyroid disorders with environmental factors like infection.

Keywords:
Cohort studiesGoiterHyperthyroidismHypothyroidism

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Area of Science:

  • Endocrinology
  • Epidemiology
  • Public Health

Background:

  • The Isfahan Thyroid Cohort Study (ITCS) is a key population-based epidemiological study in Iran.
  • It focuses on the prevalence and incidence of various thyroid disorders and iodine status.

Purpose of the Study:

  • To assess the prevalence and incidence of thyroid disorders in the Isfahan population.
  • To investigate associations between thyroid peroxidase antibody (TPOAb) levels and environmental factors in the ongoing third phase.

Main Methods:

  • The ITCS utilized multi-stage cluster sampling for participant selection in Isfahan, Iran.
  • The study included two phases (2006 and 2011) with a third phase planned for 2020-2021.
  • Data collection involved assessing thyroid function states, goiter, nodule presence, and iodine status.

Main Results:

  • Prevalence rates: Euthyroid (89.3%), overt hypothyroidism (2.8%), subclinical hypothyroidism (5.8%), overt hyperthyroidism (0.8%), and subclinical hyperthyroidism (0.99%).
  • Incidence rates per 1000 person-years: Overt hypothyroidism (2.7), subclinical hypothyroidism (20.6), overt hyperthyroidism (1.9), and subclinical hyperthyroidism (2.7).
  • Hypothyroidism and hyperthyroidism showed significant associations with goiter.

Conclusions:

  • The study provides crucial data on thyroid disorder prevalence and incidence in Isfahan.
  • The third phase of ITCS will explore the relationship between TPOAb levels and environmental factors, including infections.