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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Oct 11, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Locally Injectable Hydrogels for Tumor Immunotherapy.

Xinyi Zhang¹, Xiaonan Guo^2,3, Yan Wu⁴

¹Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.

Gels (Basel, Switzerland)

|November 29, 2021

Summary

Injectable hydrogels offer a promising platform for localized cancer immunotherapy, improving drug delivery and reducing side effects. This review explores their advancements in various combination therapies for enhanced tumor treatment.

Keywords:

cancer combined therapy immunotherapy injectable hydrogel local administration

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Area of Science:

Biomedical Engineering
Immunology
Materials Science

Background:

Hydrogel-based local delivery systems are effective platforms for cancer immunotherapy.
Injectable hydrogels enable direct delivery of antitumor drugs to the tumor site, reducing systemic toxicity.
This approach can overcome limitations of systemic drug delivery, such as low drug utilization and side effects.

Purpose of the Study:

To review recent research progress on injectable hydrogels in tumor immunotherapy.
To introduce the local delivery of multiple drugs using injectable hydrogels for various cancer treatment strategies.
To summarize the applications, challenges, and future prospects of injectable hydrogels in this field.

Main Methods:

Literature review of recent advancements in injectable hydrogels for cancer immunotherapy.
Analysis of studies focusing on local drug delivery strategies using hydrogels.
Exploration of combined therapeutic approaches including chemo-immunotherapy, radio-immunotherapy, and photo-immunotherapy.

Main Results:

Injectable hydrogels facilitate localized delivery of antitumor agents, enhancing immunotherapy efficacy.
Various combination therapies (chemo-immunotherapy, radio-immunotherapy, photo-immunotherapy) are explored using hydrogel platforms.
Hydrogels offer a minimally invasive and efficient method for localized cancer treatment.

Conclusions:

Injectable hydrogels represent a significant advancement in localized cancer immunotherapy.
Their ability to deliver multiple agents locally offers versatile therapeutic strategies.
Further research is needed to address challenges and fully realize the potential of hydrogels in tumor immunotherapy.