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Preparation of B-ring brominated derivatives of estradiol
A A Leon1, F A Mettler, M D Hylarides
1Department of Radiology, University of New Mexico, Albuquerque 87131.
Steroids
|November 1, 1986
Abstract:
The preparation of 6 beta-methoxy-7 alpha-bromoestradiol (1) is reported. Addition of in situ-generated BrOMe to 6-dehydroestradiol 3-tetrahydropyranyl ether (4a) afforded the expected addition product. Removal of the tetrahydropyranyl protective group was carried out by mild acid hydrolysis to afford 1 in good yields. This base-sensitive compound is chemically stable over long periods of time.