Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.2K
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

10
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
10

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cluster dose prediction in carbon ion therapy: using transfer learning from a pretrained dose prediction U-Net-a proof of concept.

Biomedical physics & engineering express·2026
Same author

Deep learning-based upsampling of 2D detector array measurements for patient plan verification in radiotherapy.

Medical physics·2026
Same author

Cross-section-based scaling method for material-specific cluster dose calculations - a proof of concept.

Biomedical physics & engineering express·2025
Same author

Monte Carlo simulation of beam quality correction factor<i>k</i>for carbon-ion beams using FLUKA and GATE for selected cylindrical and plane-parallel ionization chambers.

Physics in medicine and biology·2025
Same author

Determination of the beam quality correction factor <math> </math> for the PTW Semiflex 3D ionization chamber for the reference dosimetry at ZAP-X.

Journal of applied clinical medical physics·2025
Same author

A unified deep-learning framework for enhanced patient-specific quality assurance of intensity-modulated radiation therapy plans.

Medical physics·2024

Related Experiment Video

Updated: Oct 11, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.4K

Systematic end-to-end testing of multiple target treatments using the modular RUBY phantom.

Leonie Brodbek1,2, Jana Kretschmer1,2, Katrin Büsing1

  • 1University Clinic for Medical Radiation Physics, Medical Campus Pius Hospital, Carl-von-Ossietzky University Oldenburg, Germany.

Biomedical Physics & Engineering Express
|November 29, 2021
PubMed
Summary
This summary is machine-generated.

The RUBY head phantom system enables accurate end-to-end testing for complex stereotactic radiotherapy. It validates dose calculations for single-isocenter, multiple target treatments, showing good agreement with microDiamond detectors.

Keywords:
QA phantomSRS QAend-to-end testingsingle-isocenter multiple target VMATsystem QA

More Related Videos

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.3K
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

8.8K

Related Experiment Videos

Last Updated: Oct 11, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.4K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.3K
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

8.8K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Quality Assurance

Background:

  • Accurate dose verification is crucial for stereotactic treatments.
  • End-to-end testing validates the entire radiotherapy workflow.
  • The RUBY head phantom with MultiMet insert allows simultaneous dose measurements.

Purpose of the Study:

  • To assess the suitability of the RUBY head phantom system for end-to-end testing of single-isocenter, multiple target volumetric modulated arc therapy (VMAT) plans.
  • To compare dose calculations from two treatment planning systems (Oncentra Masterplan and Monaco) with experimental measurements.
  • To evaluate the performance of PinPoint 3D chambers and microDiamond detectors in complex treatment scenarios.

Main Methods:

  • Volumetric modulated arc therapy plans were optimized for artificial targets in the RUBY phantom using Oncentra Masterplan (collapsed cone algorithm).
  • Plans were recalculated using the Monaco treatment planning system (Monte Carlo algorithm).
  • Simultaneous point dose measurements were performed using PinPoint 3D chambers and microDiamond detectors at isocentric and off-axis positions on an Elekta Synergy linear accelerator.

Main Results:

  • Monaco treatment planning system calculations showed agreement within 3.5% with microDiamond detector measurements across various plans and target sizes.
  • PinPoint 3D chambers demonstrated larger discrepancies, up to 6.9%, compared to Monaco calculations.
  • Oncentra Masterplan dose calculations exhibited greater differences compared to experimental measurements.

Conclusions:

  • The RUBY head phantom system, with the MultiMet insert, is suitable for systematic end-to-end testing of single-isocenter, multiple target stereotactic treatments.
  • MicroDiamond detectors offer superior accuracy for dose verification in these complex VMAT scenarios compared to PinPoint 3D chambers.
  • The study validates the use of this phantom system for ensuring the quality and accuracy of advanced radiotherapy delivery.