Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Stanford Prison Experiment03:20

The Stanford Prison Experiment

23.9K
The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
23.9K
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

62
Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
62
Relationship Formation02:12

Relationship Formation

42.0K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
42.0K
Dark Triad and Person Perception01:29

Dark Triad and Person Perception

20
Person perception is influenced by both external behaviors and the observer’s internal characteristics, including personality traits. Individuals with dark personality traits, comprising psychopathy, Machiavellianism, and narcissism — collectively known as the dark triad – exhibit manipulative and exploitative tendencies in social contexts. These traits affect how they perceive others and how they are perceived.The Role of Dark Personality Traits in Person PerceptionBlack et...
20
Neurotransmitters01:31

Neurotransmitters

1.8K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
1.8K
Factors Influencing Attraction VI: Personality Traits01:23

Factors Influencing Attraction VI: Personality Traits

17
Personality traits are fundamental in shaping social perception and influencing interpersonal relationships. Certain traits, such as agreeableness and extraversion, contribute positively to social interactions, whereas others, such as narcissism, have complex and often contradictory effects on how individuals are perceived over time.The Role of Agreeableness and ExtraversionAgreeableness and extraversion are associated with higher levels of interpersonal attractiveness and likability.
17

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Constitutive Modeling of the Nonlinear Tensile Response of High-Strength Nanofiber Yarns Under Monotonic Loading.

Polymers·2026
Same author

Entanglement Transition in Unitary System-Bath Dynamics.

Physical review letters·2026
Same author

Impacts of concentrated leachate recirculation on methane production suppression, odorous gas emissions, and salinity accumulation in municipal solid waste.

Waste management (New York, N.Y.)·2026
Same author

Constructing Fe<sub>3</sub>N/MnO heterojunction via heteroatom doping for degrading dye wastewater by heterogeneous electro-fenton system.

Journal of environmental sciences (China)·2026
Same author

Solvent-Regulated Enantiodivergent Construction of Secondary Phosphine Oxides with P-Stereogenicity.

Organic letters·2026
Same author

Repurposing genome skimming data for non-model plant functional phylogenetics: A case study in Rhodiola.

Annals of botany·2026

Related Experiment Video

Updated: Oct 11, 2025

A Complex Diving-For-Food Task to Investigate Social Organization and Interactions in Rats
10:29

A Complex Diving-For-Food Task to Investigate Social Organization and Interactions in Rats

Published on: May 8, 2021

4.2K

Distinct Roles for Prefrontal Dopamine D1 and D2 Neurons in Social Hierarchy.

Bo Xing1, Nancy R Mack1, Yu-Xiang Zhang1

  • 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 30, 2021
PubMed
Summary

Prefrontal cortex neurons expressing dopamine D1 receptors (D1Rs) determine dominance, while D2R-expressing neurons signal subordination in male mice. Modulating these neurons

Keywords:
dopamine receptorsmousepatch clampprefrontal cortexsocial dominancesynaptic function

More Related Videos

Assessing Social Dominance in Mouse Models Using the Tube Test
03:34

Assessing Social Dominance in Mouse Models Using the Tube Test

Published on: June 6, 2025

560
Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

8.7K

Related Experiment Videos

Last Updated: Oct 11, 2025

A Complex Diving-For-Food Task to Investigate Social Organization and Interactions in Rats
10:29

A Complex Diving-For-Food Task to Investigate Social Organization and Interactions in Rats

Published on: May 8, 2021

4.2K
Assessing Social Dominance in Mouse Models Using the Tube Test
03:34

Assessing Social Dominance in Mouse Models Using the Tube Test

Published on: June 6, 2025

560
Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

8.7K

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Social Behavior

Background:

  • Neuronal activity in the prefrontal cortex (PFC) is crucial for regulating social hierarchies.
  • Dopamine (DA) modulates PFC activity via D1 receptors (D1Rs) and D2 receptors (D2Rs), but their specific roles in social dominance are unclear.

Purpose of the Study:

  • To elucidate the distinct roles of D1R- and D2R-expressing neurons in the PFC in establishing social dominance hierarchies.
  • To investigate how dopamine receptor-mediated synaptic plasticity influences intermale social rank.

Main Methods:

  • Utilized ex vivo whole-cell recordings in male mice to analyze neuronal activity.
  • Correlated dominant/subordinate status with synaptic transmission properties (AMPAR) and neuronal excitability.
  • Performed simultaneous manipulations of D1R+ neuron synaptic efficacy and D2R+ neuron excitability to alter social rank.

Main Results:

  • Dominant male mice exhibited enhanced excitatory synaptic strength onto PFC D1R+ neurons.
  • Subordinate male mice showed higher neuronal excitability in PFC D2R+ neurons.
  • Reversing these neuronal properties switched the dominant-subordinate relationship between mice.

Conclusions:

  • Prefrontal D1R+ and D2R+ neurons play distinct yet synergistic roles in establishing social hierarchy.
  • Dopamine-mediated regulation of synaptic strength in these neuronal populations is a key determinant of social rank.
  • Specific cortical microcircuits are recruited during social conflict to drive distinct dominance and subordinate behaviors.