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Feminizing adrenal tumor identified by plasma steroid profiling
Elinor Chelsom Vogt1,2, Kathrin Hammerling3, Halfdan Sorbye3,2
1Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Endocrinology, Diabetes & Metabolism Case Reports
|November 30, 2021
Summary
Feminizing estrogen-secreting adrenocortical carcinomas are rare tumors. Steroid hormone profiling using liquid chromatography mass spectrometry can aid in early diagnosis, improving patient outcomes.
Area of Science:
- Endocrinology
- Oncology
Background:
- Feminizing estrogen-secreting adrenocortical carcinomas (ACCs) are rare endocrine tumors.
- Gynecomastia is a common presenting symptom, often leading to delayed diagnosis.
Purpose of the Study:
- To highlight the diagnostic challenges of estrogen-producing ACCs.
- To emphasize the utility of steroid profiling in prompt diagnosis.
Main Methods:
- Case presentation of a patient with estrogen-secreting ACC.
- Analysis of steroid profiles using liquid chromatography mass spectrometry (LC-MS).
Main Results:
- Abnormal steroid profile was crucial for rapid diagnosis.
- LC-MS based steroid assays show potential for early detection.
Conclusions:
- Estrogen-secreting ACCs require prompt diagnosis and treatment.
- Wider adoption of LC-MS steroid assays can improve early detection rates for feminizing ACCs.
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