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Diabetic hypertriglyceridaemia and Alzheimer's disease: causal or not?
Ryusuke Takechi1, Virginie Lam, John C L Mamo
1Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Purpose Of Review:
To summarize recent findings considering type II diabetes, or metabolic syndrome dyslipidaemia with risk for Alzheimer's disease.
Recent Findings:
Population, genetic, clinical and preclinical studies support the hypothesis of increased risk for Alzheimer's disease in type 2 diabetes mellitus. The mechanisms are unclear. However, recent studies suggest that aberrations in the peripheral metabolism of triglyceride-rich-lipoproteins compromise the brain microvasculature.
Summary:
We review the literature of prediabetic metabolic syndrome and type 2 diabetes mellitus as a risk factor for Alzheimer's disease. We focus on a potential association with aberrations in the systemic metabolism of triglyceride-rich-lipoproteins reported over 18 months.
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