Related Experiment Video
Updated: Oct 11, 2025
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
The effects of maternal hypertension on the early neonatal platelet count
Peter Joslyn1, Cornelius Rosenbaum2, Andrew G Chapple2
1Department of Pediatrics Division of Neonatology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA. pjosly@lsuhsc.edu.
Objective:
To examine the relationship between maternal hypertension and early neonatal platelet counts.
Study Design:
This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) (n = 224) and infants born to normotensive mothers using multivariable logistic and Quasi-Poisson regression models.
Result:
There was no statistical difference in initial platelet counts or likelihood of thrombocytopenia (aOR = 1.19, 95% CI 0.68-2.08) between infants born to mothers with PSF and infants born to normotensive mothers after multivariable adjustment. Initial platelet counts and thrombocytopenia risk were unaffected by the presence of maternal end organ dysfunction. Small for gestational age (SGA) status was the most significant risk factor for the development of thrombocytopenia (aOR = 2.24, 95% CI 1.13-4.30).
Conclusion:
Maternal PSF does not directly affect neonatal initial platelet counts. SGA status confers the greatest risk of early thrombocytopenia.
Related Concept Videos
01:07Teratogenicity
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:33Hormonal Regulation