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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
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Recent advances in nanocarriers for nutrient delivery
Srividya Gorantla1, Geetika Wadhwa1, Shailja Jain1
1Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Drug Delivery and Translational Research
|November 30, 2021
Summary
Nutraceuticals face bioavailability challenges due to poor solubility and stability. Nanotechnology offers solutions by encapsulating bioactive molecules in nanocarriers for improved delivery and therapeutic efficacy.
Area of Science:
- Nutritional Science
- Materials Science
- Pharmaceutical Sciences
Background:
- The nutraceutical market is rapidly expanding, driven by their use in disease prevention and treatment.
- Bioactive compounds in nutraceuticals often exhibit poor solubility, low oral bioavailability, and instability.
- Challenges include degradation in the gastrointestinal tract, low aqueous solubility, and unpleasant sensory properties.
Purpose of the Study:
- To review the properties and applications of various nanocarriers for effective nutraceutical delivery.
- To highlight nanotechnology-based solutions for overcoming the limitations of bioactive molecules.
- To explore nanocarrier systems for enhanced stability, solubility, and bioavailability of nutraceuticals.
Main Methods:
- Compilation of properties and applications of diverse nanocarriers.
- Review of nanotechnology-based nutrient delivery systems.
- Analysis of nanocarriers for improving oral bioavailability of nutraceuticals.
Main Results:
- Nanotechnology-based systems significantly enhance nutraceutical stability and solubility in the gastrointestinal tract.
- Various nanocarriers, including nanoparticles, micelles, liposomes, and nanoemulsions, are effective for bioactive molecule delivery.
- These systems can overcome GIT barriers, reduce degradation, and decrease first-pass metabolism.
Conclusions:
- Nanotechnology provides a promising approach to improve the oral bioavailability and therapeutic potential of nutraceuticals.
- Effective delivery systems are crucial for maximizing the benefits of lipophilic and unstable bioactive compounds.
- The reviewed nanocarriers offer versatile platforms for developing next-generation nutraceutical formulations.
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