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Related Experiment Video

Updated: Oct 11, 2025

In Vivo Two-Photon Microscopy of Single Nerve Endings in Skin
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In Vivo Cellular-Level 3D Imaging of Peripheral Nerves Using a Dual-Focusing Technique for Intra-Neural Interface

Min Woo Lee1, Namseon Jang1, Nara Choi1

  • 1Center for Intelligent and Interactive Robotics, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 30, 2021
PubMed
Summary

This study introduces a novel optical coherence tomography imaging platform for high-resolution, in vivo 3D visualization of peripheral nerve changes around implanted electrodes, crucial for advanced prosthetics.

Keywords:
extending depth of focusintra-neural interfaceneuroprosthesisoptical coherence tomographyperipheral nerve

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Optical Imaging

Background:

  • Chronic implantation failure of intra-neural interfaces hinders natural motion and sensation restoration in amputees.
  • Current imaging technologies lack the cellular-level, 3D resolution needed to observe peripheral nerve microstructural changes in vivo.
  • Understanding these changes is vital for developing successful, long-term intra-neural interfaces.

Purpose of the Study:

  • To develop and validate an optical coherence tomography (OCT)-based imaging platform for in vivo, cellular-level, 3D visualization of peripheral nerves.
  • To assess the platform's capability in imaging microstructural nerve alterations around implanted electrodes.
  • To confirm the feasibility of this imaging approach for preclinical studies in large animals.

Main Methods:

  • Development of an OCT peripheral nerve imaging platform utilizing a novel depth of focus extension technique.
  • Achieved a point spread function with a transverse resolution of 1.27 µm for detailed imaging.
  • Performed in vivo imaging of rat and rabbit sciatic nerves with inserted metal wires.

Main Results:

  • Demonstrated cellular-level, 3D volumetric visualization of a metal wire within a rat sciatic nerve.
  • Successfully imaged microstructural changes in the rat sciatic nerve in vivo.
  • Confirmed the platform's applicability to large animals (rabbits) for preclinical assessment.

Conclusions:

  • The developed OCT imaging platform provides unprecedented in vivo, 3D, cellular-level visualization of peripheral nerve microstructures.
  • This technology offers a powerful tool for studying nerve responses to implanted electrodes.
  • It is expected to significantly advance the development of chronic intra-neural interfaces for amputees.