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Effect of transfusion on immune function in a traumatized animal model
Archives of Surgery (Chicago, Ill. : 1960)
|January 1, 1986
Summary
Blood transfusions may worsen immune suppression in trauma patients. This study found transfusions impaired cell-mediated immunity and macrophage migration in burned rats, suggesting a negative impact on immune function post-trauma.
Area of Science:
- Immunology
- Transfusion Medicine
- Trauma Research
Background:
- Blood transfusions are known to prolong allograft survival, likely via suppressor T lymphocyte stimulation.
- The impact of transfusions on immune function in traumatized patients remains under-investigated.
Purpose of the Study:
- To investigate the effects of blood transfusions on the immune system in a burned rat model.
- To determine if transfusions exacerbate immune suppression associated with trauma.
Main Methods:
- A burned rat model was utilized to simulate trauma.
- Animals received blood transfusions.
- Immune function parameters including white blood cell counts, differential cell count, neutrophil migration, bactericidal index, cell-mediated immunity, and macrophage migration were assessed.
Main Results:
- Transfusions did not affect white blood cell counts, differential counts, or neutrophil function.
- Animals receiving transfusions showed impaired cell-mediated immunity.
- Macrophage migration was also reduced in transfused animals.
Conclusions:
- Blood transfusions appear to worsen the immunosuppression already present in trauma patients.
- Transfusions may negatively impact critical immune responses, including cell-mediated immunity and macrophage function, following severe injury.