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Updated: Oct 11, 2025

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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene
Kesar Jagdev1, Damiano Tanini2, Jack W Lownes1
1School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. r.s.grainger@bham.ac.uk.
Organic & Biomolecular Chemistry
|November 30, 2021
Abstract:
Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.
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