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Updated: Oct 11, 2025

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Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
Published on: February 22, 2020
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Transcranial magnetic stimulation implementation on stroke prognosis.
Stella Karatzetzou1, Dimitrios Tsiptsios2,3, Aikaterini Terzoudi1,4
1Neurology Department, Democritus University of Thrace, Alexandroupolis, Greece.
Summary
Transcranial magnetic stimulation (TMS) can predict stroke recovery. Motor evoked potentials (MEPs) from TMS indicate good prognosis, while their absence suggests poor outcomes for stroke survivors.
Area of Science:
- Neuroscience
- Neurology
- Rehabilitation Medicine
Background:
- Stroke is a leading cause of disability, necessitating accurate prognosis for motor recovery.
- Predicting stroke outcomes is crucial for effective patient management and rehabilitation planning.
- Transcranial magnetic stimulation (TMS) is explored as a biomarker for stroke prognosis.
Purpose of the Study:
- To review the literature on the utility of TMS in forecasting stroke survivors' motor recovery potential.
- To evaluate TMS as a prognostic tool for post-stroke functional outcomes.
Main Methods:
- A systematic literature search was performed on MEDLINE and Scopus databases.
- Studies published between 1990 and 2021, in English, focusing on TMS for stroke prognosis were included.
- Thirty-nine relevant articles were identified and included in this review.
Main Results:
- Motor evoked potentials (MEPs) recording via TMS is a strong indicator of favorable motor recovery.
- Absence of MEPs typically correlates with a poor prognosis for functional recovery after stroke.
- Other TMS parameters, like motor threshold and central motor conduction time, also show correlations with recovery rates.
Conclusions:
- TMS is a non-invasive, rapid, safe, and reproducible method for assessing stroke prognosis.
- MEP assessment using TMS can help resolve prognostic uncertainties in stroke patients.
- TMS provides valuable insights into the potential for motor recovery in stroke survivors.
Keywords:
Cerebrovascular diseaseMotor evoked potentialsPrognosisRecoveryStrokeTranscranial magnetic stimulation
