Association of white matter volume with sleep quality: a voxel-based morphometry study

Many studies have focused on the gray matter volume associated with sleep quality, little is known about the relationship between white matter volume and sleep quality. Brain white structure is a crucial component in the structural neuroanatomy. Therefore, in this study, we investigated the association between white matter volume and sleep quality. Data were collected using the Pittsburgh Sleep Quality Index and voxel-based morphometry among 352 college students. Results showed that the global PSQI score was negatively associated with the white matter volume, including in the right middle occipital gyrus, the left superior temporal gyrus, the right the precentral gyrus, the left supramarginal gyrus, the left middle frontal gyrus, the left precunes, and the right superior frontal gyrus. Results also indicated that the white matter volume in specific regions negatively associated with the factor of PSQI. These specific brain regions may be replicated in brain areas related to sleep quality. In summary, we suggested that exploring brain white structure are related to sleep could help to expound the mechanisms by which sleep quality are associated with brain function, behavior and cognition, as well as potentially the networks and systems responsible for variations in sleep themselves.