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Published on: April 16, 2019
Chiglitazar: First Approval
1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com.
Chiglitazar, a PPAR agonist, is approved in China for type 2 diabetes management. This oral medication aids glycaemic control alongside diet and exercise, with ongoing research for non-alcoholic steatohepatitis.
Area of Science:
- Pharmacology and Drug Development
- Metabolic Diseases
- Hepatology
Background:
- Chiglitazar is an oral, non-thiazolidinedione PPAR agonist targeting alpha, delta, and gamma receptors.
- It is developed by Chipscreen Biosciences for type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH).
Purpose of the Study:
- To summarize the development milestones of chiglitazar.
- To highlight its recent approval for type 2 diabetes treatment.
Main Methods:
- Review of chiglitazar's development pathway.
- Analysis of clinical development status and regulatory milestones.
Main Results:
- Chiglitazar received approval in China in October 2021.
- It is indicated as an adjunct to diet and exercise for glycaemic control in adult T2D patients.
- Phase 2 clinical development for NASH is ongoing in China.
Conclusions:
- Chiglitazar represents a significant advancement in T2D treatment.
- Its multi-PPAR agonism offers a novel therapeutic approach.
- Further development for NASH is anticipated.
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