Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fattening mother's milk with oxytocin.

Science signaling·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

RXRα marks the spot for Crohn's disease.

Science signaling·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026

Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions
08:47

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

2.7K

A message for microglia from microbiota.

Wei Wong1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|November 30, 2021
PubMed
Summary
This summary is machine-generated.

Microbiota-produced acetate regulates microglia function via epigenetic and mitochondrial pathways. This finding highlights the gut microbiome

More Related Videos

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.0K
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

33.3K

Related Experiment Videos

Last Updated: Oct 11, 2025

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions
08:47

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

2.7K
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.0K
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

33.3K

Area of Science:

  • Neuroimmunology
  • Microbiome Research
  • Epigenetics

Background:

  • Microglia are the primary immune cells of the central nervous system.
  • The gut microbiome influences host physiology and immunity.
  • Acetate is a major short-chain fatty acid produced by gut bacteria.

Purpose of the Study:

  • To investigate the role of microbiota-derived acetate in regulating microglia function.
  • To elucidate the mechanisms by which acetate affects microglia.

Main Methods:

  • In vitro studies using primary microglia cultures.
  • In vivo studies using mouse models.
  • Epigenetic analysis (e.g., histone acetylation).
  • Mitochondrial respiration assays.

Main Results:

  • Acetate directly modulated microglia activation states.
  • Epigenetic modifications, specifically histone acetylation, were observed in response to acetate.
  • Acetate influenced mitochondrial respiration and ATP production in microglia.
  • Microbiota-depleted mice showed altered microglia function, which was partially restored by acetate administration.

Conclusions:

  • Microbiota-derived acetate is a key regulator of microglia function.
  • Acetate exerts its effects through epigenetic and mitochondrial mechanisms.
  • Targeting the gut microbiome or acetate metabolism may offer therapeutic strategies for neuroinflammatory conditions.