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Rectal bleeding induced by Dipyridamole.

I Bayer, S Kyzer, D Creter

    Diseases of the Colon and Rectum
    |February 1, 1986
    PubMed
    Summary
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    Dipyridamole treatment in patients with hemorrhoids was associated with significant rectal bleeding. This bleeding resolved upon drug discontinuation, suggesting a causal link.

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Rectal bleeding is a common symptom with various causes.
    • Hemorrhoids are a frequent finding in patients experiencing rectal bleeding.

    Purpose of the Study:

    • To investigate the relationship between Dipyridamole use and rectal bleeding in patients with hemorrhoids.

    Main Methods:

    • Evaluation of 19 patients on continuous Dipyridamole therapy for rectal bleeding.
    • Comparison with six control patients.
    • Assessment for hemorrhoids and contact bleeding.

    Main Results:

    • All 19 patients had hemorrhoids.
    • 13 patients experienced overt rectal bleeding.
    • 16 patients showed contact bleeding, which persisted despite treatment and ceased only after Dipyridamole withdrawal.

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    Conclusions:

    • Continuous Dipyridamole therapy may induce or exacerbate rectal bleeding in patients with hemorrhoids.
    • Drug withdrawal is an effective measure to manage Dipyridamole-associated rectal bleeding.