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Senotherapeutic Drugs: A New Avenue for Skincare?

Ben P Lee1, Lorna W Harries1

  • 1From SENISCA; and University of Exeter Medical School, University of Exeter.

Plastic and Reconstructive Surgery
|November 30, 2021
PubMed
Abstract

Insights

Cellular senescence drives skin aging. Emerging senotherapeutic interventions, including senolytics and senomorphics, offer new ways to combat aging by targeting senescent cells and improving mRNA processing for healthier skin.

Area of Science:

  • Gerontology
  • Dermatology
  • Molecular Biology

Background:

  • Skin aging is a visible sign of systemic aging processes.
  • Cellular senescence, the accumulation of aging cells, is a key driver of aging.
  • Hallmarks of aging include cellular senescence and dysregulated mRNA processing.

Purpose of the Study:

  • To review the role of cellular senescence in skin aging.
  • To discuss emerging senotherapeutic interventions for skin aging.
  • To explore oligonucleotide therapeutics for manipulating mRNA processing.

Main Methods:

  • Literature review of cellular senescence and aging hallmarks.
  • Analysis of senolytic and senomorphic therapeutic strategies.
  • Discussion of oligonucleotide therapeutics for mRNA processing.

Main Results:

  • Cellular senescence significantly contributes to skin aging.
  • Senolytics and senomorphics are promising interventions.
  • Oligonucleotide therapeutics offer a novel approach to target mRNA processing.

Conclusions:

  • Senotherapeutics represent a revolutionary approach to treating skin aging.
  • Targeting cellular senescence and mRNA processing can improve skin health.
  • Senotherapies are emerging as a new class of skincare interventions.

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