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Sister chromatid exchange in immature haemopoietic cells, T- and B-lymphocytes
T-lymphocytes, B-lymphocytes, and cells derived from human haemopoietic progenitor cells were analysed for their sister chromatid exchange (SCE) rate. T- and B-lymphocytes were separated and stimulated with phytohaemagglutinin (PHA) and Epstein Barr (EB) virus respectively, while the progenitor cells were cultured in the mixed colony assay. B-lymphocytes had a significantly lower SCE rate than either the T-lymphocytes or cells derived from progenitor cells.
T-lymphocytes, B-lymphocytes, and cells derived from human haemopoietic progenitor cells were analysed for their sister chromatid exchange (SCE) rate. T- and B-lymphocytes were separated and stimulated with phytohaemagglutinin (PHA) and Epstein Barr (EB) virus respectively, while the progenitor cells were cultured in the mixed colony assay. B-lymphocytes had a significantly lower SCE rate than either the T-lymphocytes or cells derived from progenitor cells.