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Updated: Oct 11, 2025

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
Published on: February 17, 2023
Construction of synergistic pH/H2O2-responsive prodrug for prolonging blood circulation and accelerating cellular
Jun Liu1, Shuang Si1, Jinyi Xu1
1College of Chemistry and Chemical Engineering, Hexi University, Zhangye City 734000, Gansu Province, PR China.
Abstract:
We have developed a real-time and multifunctional doxifluridine-conjugate prodrug (LYX), which involved the preliminary methylfluorescein with 5-fluorouracil linker as protecting group, the targeting biotin unit, and a model therapeutic drug (doxifluridine). The shielding group (5'-DFUR) was found to be effective in prolonging circulation at physiological pH 7.4 and improving accumulation in the acidic microenvironment of the tumor. Based on this strategy, the stability and stimulus responsive properties of prodrug could enhance drug release efficiency and exhibit fewer side effects, thereby providing a unique opportunity for diagnosis and imaging additional analytes or enzymatic activities.
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