ISFMDA: Learning Interactions of Selected Features-Based Method for Predicting Potential MicroRNA-Disease...

Prediction of potential microRNA-disease associations is one of the important tasks in computational biology fields. Mining more sophisticated features can improve the performance of the prediction methods. This article proposes a novel algorithm (ISFMDA) that can effectively learn low- or high-order interactions of recursive feature elimination selected features by an extreme gradient boosting, a factorization machine, and a deep neural network. As a result, ISFMDA can obtain an area under receiver operating characteristic curve (AUROC) of 0.9342 ± 0.0007 in fivefold cross-validation tests with 51.25% of original features, which verifies the effectiveness of the methods.