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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Updated: Oct 11, 2025

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Expression and function of PDGF-C in development and stem cells.

Yi Tian1, Ying Zhan1, Qin Jiang2

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, People's Republic of China.

Open Biology
|December 1, 2021
PubMed
Summary
This summary is machine-generated.

Platelet-derived growth factor C (PDGF-C) plays key roles in development and stem cell regulation. Understanding PDGF-C expression and function is crucial for various research fields.

Keywords:
developmentembryogenesisorganogenesisplatelet-derived growth factor Cpluripotencystem cell

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Area of Science:

  • Biochemistry
  • Developmental Biology
  • Cell Biology

Background:

  • Platelet-derived growth factor C (PDGF-C) is a recently identified member of the PDGF family.
  • PDGF-C exhibits broad expression across organs and cell types.
  • Over the past two decades, PDGF-C has been implicated in diverse biological processes.

Purpose of the Study:

  • To review the expression and functions of PDGF-C and its receptors.
  • To focus on the roles of PDGF-C in development and stem cell biology.

Main Methods:

  • Literature review of studies on PDGF-C.
  • Analysis of PDGF-C expression patterns.
  • Examination of PDGF-C functions in developmental and stem cell contexts.

Main Results:

  • PDGF-C is involved in numerous physiological and pathological processes, including development, angiogenesis, tumor growth, tissue remodeling, wound healing, atherosclerosis, fibrosis, and stem/progenitor cell regulation.
  • PDGF-C and its receptors are critical regulators in development.
  • PDGF-C influences stem and progenitor cell behavior.

Conclusions:

  • PDGF-C is a significant growth factor with diverse roles.
  • Further understanding of PDGF-C in development and stem cells is essential for advancing biological and medical research.