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Evaluation of the Relationship between Fat Volume and Nephrolithiasis
Sedat Tastemur1, Samet Senel1, Esin Olcucuoglu2
1Department of Urology, Ankara City Hospital, Ankara, Turkey.
Current Medical Imaging
|December 1, 2021
Summary
Increased perirenal fat volume, a visceral fat measurement, is linked to kidney stones. Specifically, a total perirenal fat volume exceeding 387cm³ independently elevates kidney stone risk.
Area of Science:
- Nephrology
- Radiology
- Obesity Medicine
Background:
- Visceral fat accumulation, particularly perirenal fat, is increasingly recognized as a metabolic risk factor.
- Understanding the relationship between specific fat depots and kidney stone formation is crucial for risk stratification.
Purpose of the Study:
- To investigate the association between perirenal fat volume and the presence of kidney stones.
- To determine if perirenal fat volume is an independent risk factor for kidney stone development.
Main Methods:
- A cohort of 169 patients was divided into control and unilateral kidney stone groups.
- Contrast-enhanced abdominal computed tomography (CT) scans were utilized to quantify perirenal fat volume.
- Statistical comparisons were made between groups and between stone-bearing and non-stone-bearing kidneys.
Main Results:
- Total perirenal fat volume was significantly higher in patients with kidney stones compared to controls.
- In the kidney stone group, perirenal fat volume was greater in the stone-bearing kidney than the contralateral kidney.
- A total perirenal fat volume greater than 387cm³ was identified as a risk factor for kidney stones via ROC analysis.
Conclusions:
- Perirenal fat volume is directly correlated with kidney stone formation.
- Elevated total perirenal fat volume (>387cm³) is an independent predictor of kidney stones, outperforming BMI.
- Hypertension and hyperlipidemia were also confirmed as independent risk factors.
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