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Airway management in mucopolysaccharidosis: a retrospective case series review

Murat Tümer1, Aysun Ankay Yılbaş1, Sehend Debbağ1

  • 1Hacettepe University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey.

Brazilian Journal of Anesthesiology (Elsevier)
|December 1, 2021
PubMed

Insights

Managing airways in mucopolysaccharidosis patients undergoing surgery presents challenges. Video laryngoscopy appears safe, but alternative airway management techniques are crucial, especially for older patients.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Genetic Disorders

Background:

  • Mucopolysaccharidosis (MPS) encompasses a group of rare genetic disorders.
  • Airway management in MPS patients undergoing surgery is often complex.
  • This study reviews surgical airway management in MPS patients.

Observation:

  • A retrospective review of 31 surgeries in MPS patients (2015-2019) was conducted.
  • The mean patient age was 127.6 months; MPS-IV and MPS-VI were most frequent.
  • Orthopedic surgeries were most common, with difficult intubation in 10 procedures.

Findings:

  • Difficult intubation occurred in 10 procedures, exclusively in patients over 36 months old.
  • Video laryngoscopy was the primary intubation method utilized.
  • Seventeen patients required intensive care unit (ICU) follow-up.

Implications:

  • Video laryngoscopy demonstrates safety in MPS patients for airway management.
  • Anesthesiologists must maintain preparedness for alternative airway techniques.
  • Age over 36 months may be a risk factor for difficult intubation in MPS patients.
Keywords:
Airway managementDifficult airwayMucopolysaccharidosis

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