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Thermogenic mechanisms and their control.

J Himms-Hagen, J Cerf, M Desautels

    Experientia. Supplementum
    |January 1, 1978
    PubMed
    Summary

    Cold acclimation enhances non-shivering thermogenesis in rats by altering mitochondria and plasma membranes. Preventing mitochondrial changes with oxytetracycline blocks this enhanced calorigenic response to catecholamines.

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    Area of Science:

    • Physiology
    • Cell Biology
    • Metabolism

    Background:

    • Cold exposure triggers adaptive responses in brown adipose tissue and skeletal muscle.
    • Non-shivering thermogenesis is a key metabolic process for heat production.
    • Catecholamines play a crucial role in regulating metabolic rate.

    Purpose of the Study:

    • To review adaptive changes in mitochondria and plasma membranes during cold acclimation.
    • To investigate the relationship between these cellular changes and non-shivering thermogenesis.
    • To understand the role of these adaptations in the enhanced calorigenic action of catecholamines.

    Main Methods:

    • Review of existing literature on cold-acclimated rats.
    • Analysis of morphological and functional properties of mitochondria and plasma membranes.
    • Investigation of the effects of oxytetracycline on cold acclimation responses.

    Main Results:

    • Cold acclimation induces significant alterations in mitochondrial and plasma membrane properties in brown adipose tissue and skeletal muscle.
    • Oxytetracycline treatment prevents these morphological mitochondrial changes.
    • Prevention of mitochondrial changes also inhibits the development of enhanced calorigenic response to catecholamines.

    Conclusions:

    • Mitochondrial and plasma membrane alterations are closely linked to the development of non-shivering thermogenesis.
    • These observed changes may be a causal factor or a secondary consequence of increased thermogenesis.
    • Further research is needed to elucidate the precise mechanisms involved.

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